Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA bindingand degradation
نویسندگان
چکیده
منابع مشابه
Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA bindingand degradation
Cells adapt to changes in ambient oxygen by changing their gene expression patterns. In fission yeast, the sterol regulatory element-binding protein Sre1 is proteolytically cleaved under low oxygen, and its N-terminal segment (Sre1N) serves as a hypoxic transcription factor. When oxygen is present, the prolyl hydroxylase Ofd1 down-regulates Sre1N activity in two ways: first, by inhibiting its b...
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Sre1, the fission yeast sterol regulatory element-binding protein, is an ER membrane-bound transcription factor that controls adaptation to low oxygen growth. Under low oxygen, Sre1 is proteolytically cleaved and the N-terminal transcription factor domain (Sre1N) is released from the membrane and enters the nucleus to activate hypoxic gene expression. Ofd1, a prolyl 4-hydroxylase-like 2-oxoglut...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2012
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e12-06-0451